How is blood glucose regulated when we exercise?

How is blood glucose regulated when we exercise? https://noticiasdelaciencia.com/upload/images/12_2018/9857_como-se-regula-la-glucosa-en-sangre-cuando-hacemos-ejercicio_image_380.jpg?36

How is blood glucose regulated when we exercise?





The regulation of blood glucose levels is essential to prevent and maintain controlled diseases such as diabetes, which already affects one in eleven people in Spain and causes 25,000 deaths per year in the country, according to data from the Spanish Diabetes Federation . Therefore, knowing how to regulate glucose levels in our body in different situations becomes crucial for experts.

 

A study led by the Mayo Clinic in Rochester (Minnesota, USA) and in which Ana Belén Peinado, researcher from the Department of Health and Human Performance of the Polytechnic University of Madrid (UPM), has participated, throws new data on the role that Peripheral chemoreceptors of the carotid bodies -responsible for the regulation of respiration- perform in the control of glucose levels when an intense aerobic exercise is being practiced with an intravenous infusion of dopamine.

 

"Changes in glucose levels in the peripheral or central blood are detected by glucose sensors located in the hypothalamic nuclei, the pancreas, the nucleus of the solitary tract, the hepatic portal system and the receptors of the carotid body", explains Hairstyle.

 

"The results indicate that plasma glucose and the secretion of certain glycoregulatory hormones are attenuated when a low dose of exogenous dopamine is administered during a prolonged aerobic exercise in trained subjects," he adds. The work has been published in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

 



 

One in eleven people in Spain has diabetes, a disease that causes 25,000 deaths per year in the country. (Photo: UPM)

 

"This suggests that the peripheral chemoreceptors of the carotid bodies, or other glucurregulatory organs with dopamine receptors, can contribute to the regulation of blood glucose in exercise in active individuals," says the researcher at the UPM.

 

The novelty of this work, carried out during a postdoctoral stay thanks to a José Castillejo scholarship, is that it is the first study in humans that specifically assesses the role of chemoreceptors of carotid bodies in the regulation of blood glucose during a normal physiological stimulus, as is exercise. "This work can establish an experimental model to study the regulation of glycemia in additional experiments, including patients with type 1 and type 2 diabetes," he says.

 

The research also provides new data on the pathologies related to the poor regulation of blood glucose in people with type 2 diabetes, establishing that, in many cases, they also have problems with sleep apnea and altered hypoxia responses. "This could be explained by an alteration in the response of the carotid chemoreceptors, which would contribute to the pathophysiology of diabetes in this population," continues Ana Belén Peinado. (Source: IUMP)
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