Wearable bioreactor for limb regeneration

Wearable bioreactor for limb regeneration https://i0.wp.com/www.eresviral.com/wp-content/uploads/2018/11/Biorreactor-ponible-para-regeneración-de-extremidades.jpg?fit=260%2C80&ssl=1

Wearable bioreactor for limb regeneration







The results of recent experiments show that supplying progesterone where an amputation has occurred can induce the regeneration of limbs in adult frogs that would not otherwise regenerate. This discovery constitutes an important advance in the knowledge of the biological mechanisms that govern the regeneration of lost limbs, and could help to take a decisive step towards treatments capable of regrowing amputated limbs.



The team of Celia Herrera-Rincon, of the Tufts University in the campus of Medford / Somerville, of Massachusetts, the United States, created a wearable bioreactor, that was placed in the zone of the stump left by an amputation of extremity. The bioreactor delivered progesterone locally for a period of 24 hours, after which Herrera-Rincon and his colleagues observed that it had a beneficial and long-lasting effect on tissue regrowth. This effect allowed the frogs to partially regenerate their hind limbs. The mere exposure for 24 hours led to nine months of changes in gene expression, innervation and organized tissue growth.



The results of these experiments suggest that the device and the drug could be the first step to develop treatments capable of inducing the regeneration of limbs in species in which it does not occur.







A wound on the end of an adult frog usually leads to the formation of a cartilaginous "spike" (left). However, treatment with progesterone using a silk hydrogel device for 24 hours led to the formation of an oar-shaped structure (right). (Photos: Celia Herrera-Rincon, Allen Discovery Center, Tufts University)



Many animal species are capable of regeneration, in fact, certain worms and sea cucumbers can give rise to complete individuals from fragments detached when cut into pieces. In other species, a partial regeneration is appreciated, for example, the lizards re-grow their tails, some crabs do the same with their claws, and the deer renew their horns every year. The frog Xenopus laevis, examined in this study, can regenerate limbs when it is in its tadpole phase or just after leaving that stage, but gradually loses that capacity as it develops and becomes an adult.



Until now, it was not known if adult frogs were capable of a significant regeneration response.



For the Human Being, the ability to regenerate would mark a before and after, especially for people living with limb amputations. Only in the United States, the number of these people is about two million.



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