The removal of the appendix is ​​related to the decrease in the risk of Parkinson's disease in...

The removal of the appendix is ​​related to the decrease in the risk of Parkinson's disease in... https://i2.wp.com/www.eresviral.com/wp-content/uploads/2018/11/La-extirpación-del-apéndice-está-relacionada-con-la-disminución-del-riesgo-de-enfermedad-de-Parkinson-en-aproximadamente-el-20-por-ciento-de-los-casos.jpg?fit=260%2C90&ssl=1

The removal of the appendix is ​​related to the decrease in the risk of Parkinson's disease in approximately 20 percent of cases





The removal of the appendix is ​​related to the decrease in the risk of Parkinson's disease in approximately 20 percent of cases


A large-scale epidemiological analysis of more than one million people in Sweden has shown that removal of the appendix is ​​associated with a reduced risk of Parkinson's disease (PD) in almost 20% of cases, a finding that implies that Tiny organ could contribute to the onset of such condition.



Researchers report this finding, while requesting more epidemiological studies to confirm the effect of appendectomy on the risk of PD. PD, a common and incurable neurodegenerative disorder, represents a massive health and financial burden in the United States. UU., With a million people affected in the US UU., That supposed more than 14 000 million dollars in medical expenses in the country only in 2010.



According to the forecasts, by the year 2040, the incidence of PE in the US will double. UU., Which underscores the urgent need to develop more effective interventions. Previous research has shown that abnormalities in the gastrointestinal tract are common in PD, which can precede motor symptoms by up to 20 years.



On this occasion, Bryan Killinger and his colleagues investigated the connection between PD and the appendix, which has been shown to contain high amounts of α-synuclein, a protein that is added to the brains of patients with PD. They studied a set of epidemiological data that contained demographic information and statistical data on PE for 1.6 million people in Sweden, finding that appendectomy reduced the overall risk of developing PE by 19.3%.







(Photo: B.A. Killinger et al., Science Translational Medicine (2018))



Interestingly, appendectomy was found to be associated with the greatest risk reduction effect among rural dwellers, suggesting that the effects of the procedure could counteract environmental risk factors, such as exposure to pesticides, that have been linked to an increased risk of EP. The analysis of a second data set of 849 patients with PD revealed that appendectomy was associated with a late onset of PD in an average of 3.6 years of life later.



Killinger et al. they also examined the appendages of healthy individuals and found that they contained chemically active α-synuclein prone to harmful aggregation. According to the authors, therapies aimed at the accumulation of α-synuclein in the appendix and intestine should be investigated as a possible early intervention strategy to reduce the risk of PD at a later age. (Source: AAAS)

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