The identification of a new function of a protein opens the door to new treatments against obesity

The identification of a new function of a protein opens the door to new treatments against obesity https://i0.wp.com/www.eresviral.com/wp-content/uploads/2018/11/La-identificación-de-una-nueva-función-de-una-proteína-abre-la-puerta-a-nuevos-tratamientos-contra-la-obesidad.jpg?fit=219%2C146&ssl=1

The identification of a new function of a protein opens the door to new treatments against obesity





The identification of a new function of a protein opens the door to new treatments against obesity





Obesity is one of the most frequent nutritional problems in the population of developed countries and is considered one of the greatest epidemics of the 21st century. That is why research into new treatments for the control and eradication of this pathology is one of the priorities of the scientific community in the international arena.



The Lipobeta research group at the Rey Juan Carlos University (URJC) (Spain), led by Dr. Gema Medina-Gomez, has been studying new signaling pathways for the treatment of obesity for a decade. The latest trials, based on the combination of clinical studies in patients and experimental animal models, have resulted in the identification of the isoform 3 of the transforming growth factor, TGFb3, as the molecule involved.



This type of protein would stimulate the proliferation of fatty cells of the body's fatty tissue. "TGFb3 is expressed specifically in subcutaneous adipose tissue, stimulating the proliferation of adipocyte precursors and regulating the number of cells with fat," explains Dr. Gema Medina-Gomez.







Obesity. (Photo: URJC)



The results of this research, carried out in collaboration with the group of Dr. Mikael Rydén and Dr. Peter Arner of the Karolinska Institute of Sweden, have recently been published in the scientific journal Cell Reports. The main objective of this collaborative project, according to the URJC researcher, "consists of the study of new regulatory molecules that control the number of adipocytes in the changes that occur during the expansion of adipose tissue in obesity."



Researchers have observed that this growth factor is involved in the interaction between morphology and adipose tissue expansion with glucose metabolism. This finding opens new avenues for the study of target molecules in the treatment of obesity. "One of the main applications of this study will be the identification of molecules involved in the morphological changes of adipose tissue of obese people after weight loss," concludes Dr. Gema Medina-Gomez. (Source: URJC / DICYT)



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