Skin ages due to loss of identity and function of the main cells of the dermis

Skin ages due to loss of identity and function of the main cells of the dermis https://i0.wp.com/www.eresviral.com/wp-content/uploads/2018/11/La-piel-envejece-por-la-pérdida-de-identidad-y-función-de-las-células-principales-de-la-dermis.jpg?fit=146%2C146&ssl=1

Skin ages due to loss of identity and function of the main cells of the dermis





Skin ages due to loss of identity and function of the main cells of the dermis


As our tissues age, they lose their function and their ability to regenerate in the face of different damages. A paper published today in Cell by researchers of the Institute of Biomedical Research (IRB Barcelona) and the National Center for Genomic Analysis of the Center for Genomic Regulation (CNAG-CRG) (Spain), explains the aging process of fibroblasts of the dermis.



The main conclusion is that these cells lose their cellular identity, as if they "forgot" what they are, altering their function and affecting the tissue. The study reveals cellular and molecular pathways affected over time and whose modulation, according to the researchers, could delay or even reverse the aging of the skin.



Dermal fibroblasts are essential to produce the collagens and other proteins that make up the dermis and allow the skin to maintain its barrier function properly. In addition, its function is essential during the repair of skin wounds. As we get older, the dermis loses the ability to maintain the production of collagens and sees its ability to repair very diminished wounds.



"This leads to many problems for older people, as they do not heal well and the skin barrier is defective, which increases the predisposition for skin and systemic infections," explains Salvador Aznar Benitah, ICREA researcher at IRB Barcelona and responsible for the investigation. "That the loss of cell identity is one of the causes of aging is a very interesting concept that we believe had not been observed before," he concludes.







(Photo: M. Salzer, IRB Barcelona)



Holger Heyn, researcher of the CNAG-CRG and co-leader of this study, explains that "cutting-edge technologies allow cell-to-cell molecular analysis. In this work, we have used these advanced methods to obtain a high-resolution view of fibroblasts as they get older. "



The study, whose first author is the doctoral student at IRB Barcelona, ​​Marion Salzer, shows that during aging, skin fibroblasts acquire many characteristics of adipocytes (fat cells). "This means that they lose their cell identity and that they also stop producing and secrete collagens as they should," explains Salzer.



The unicellular analysis confirmed this loss of identity of the fibroblasts in elderly animals. Using sophisticated computational tools, the scientists observed that aged fibroblasts show a less defined molecular conformation compared to their young counterparts and that "they seem to revert to cellular states observed in newborn animals," Heyn says.



Although it is a basic research, Aznar Benitah emphasizes that "this new knowledge could not only have cosmetic applications, such as anti-wrinkle, but what is much more important, therapeutic applications aimed at making people's skin older heal better and more efficiently after a wound or an operation. " (Source: CRG)

        .

  !function(f,b,e,v,n,t,s)

  {if(f.fbq)return;n=f.fbq=function(){n.callMethod?

  n.callMethod.apply(n,arguments):n.queue.push(arguments)};

  if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';

  n.queue=[];t=b.createElement(e);t.async=!0;

  t.src=v;s=b.getElementsByTagName(e)[0];

  s.parentNode.insertBefore(t,s)}(window, document,'script',

  'https://connect.facebook.net/en_US/fbevents.js');

  fbq('init', '369524843414444');

  fbq('track', 'PageView');

    .


SOURCE LINK ERESVIRAL.COM 
https://www.beviral.online