Myasthenia gravis, related to alterations in the intestinal microbiota

Myasthenia gravis, related to alterations in the intestinal microbiota https://i2.wp.com/www.eresviral.com/wp-content/uploads/2018/11/La-miastenia-grave-relacionada-con-alteraciones-en-la-microbiota-intestinal.jpg?fit=200%2C146&ssl=1

Myasthenia gravis, related to alterations in the intestinal microbiota







Myasthenia gravis could be related to alterations in the intestinal microbiota, formed by microorganisms, especially bacteria, that inhabit the intestine. This is the main conclusion of a new study led by researchers from the Spanish National Research Council (CSIC) (Spain) published in the journal Scientific Reports.



Myasthenia Gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of muscle weakness and in which neuromuscular communication is affected. It is caused by the presence of antibodies that attack the proteins involved in the neuromuscular synapse (the union between a neuron and a muscle fiber).



The results obtained show, for the first time, an alteration of the intestinal microbiota in patients with this condition, who have higher levels of Gram-negative bacteria, such as Bacteroidetes, and lower levels of other microorganisms, such as bifidobacteria, than individuals of healthy control.







Intestinal microbiota. (Photo: DICYT)



"We know that the intestinal microbiota, in addition to digesting food, helps our defense system against diseases and even interferes with neurological development. In addition to the knowledge about alterations of the microbiota in other autoimmune diseases, the results of this study extend these observations to autoimmune neuromuscular diseases, "explains CSIC researcher Miguel Gueimonde, of the Institute of Dairy Products of Asturias (CSIC).



This initial investigation included 10 patients and 10 control subjects of the same sex and age. The scientists analyzed the composition of the intestinal microbiota, its activity by quantifying the levels of major microbial metabolites present in the intestine (short chain fatty acids), and determined the microbial composition by massive sequencing of the rRNA gene 16S.



"This is a previous study, but if the role of the microbiota in this disease is confirmed, it would be possible to develop strategies to complement the treatment of patients with products capable of modulating or changing their intestinal microbiota in a beneficial way," adds Gueimonde. . (Source: CSIC / DICYT)

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