High levels of vitamin D, related to better metabolic health in women with postmenopausal osteoporosis

High levels of vitamin D, related to better metabolic health in women with postmenopausal osteoporosis https://i0.wp.com/www.eresviral.com/wp-content/uploads/2018/11/Altos-niveles-de-vitamina-D-relacionados-con-mejor-salud-metabólica-en-mujeres-con-osteoporosis-posmenopáusica.jpg?fit=195%2C146&ssl=1

High levels of vitamin D, related to better metabolic health in women with postmenopausal osteoporosis





High levels of vitamin D, related to better metabolic health in women with postmenopausal osteoporosis





Postmenopause is a physiological but critical stage in a woman's life that is associated with an increase in bone fragility and cardiovascular risk. Alterations in glucose metabolism are a common factor in both entities. Researchers of the CIBER of Fragility and Healthy Aging (CIBERFES) (Spain) led by Manuel Muñoz Torres of the Department of Medicine of the University of Granada (Biosanitary Research Institute of Granada), have verified that the circulating levels of 25-hydroxyvitamin D (a form of vitamin D, also known as 25 (OH) D) are related to a better metabolism of glucose in women with postmenopausal osteoporosis, being able to demonstrate this relationship in the presence of concentrations of 25 (OH) D above the optimal value established until the moment. These results have been published in the Journal of Women's Health.



This is the conclusion of the cross-sectional study that the researchers presented with a sample of 40 women with postmenopausal osteoporosis in which they determined the serum levels of 25 (OH) D and the parameters of glucose homeostasis (glucose and insulin levels and insulin levels). resistance and sensitivity to insulin), in addition to evaluating anthropometric, biochemical, clinical and bone markers parameters.







Researchers who have carried out the study. (Photo: CIBER)



Currently, there is no solid evidence on what levels of 25 (OH) D would be optimal to achieve benefits on glucose metabolism, as well as on other health objectives such as the prevention of cardiovascular disease. Hence, one of the objectives of this research was to establish the optimal concentration of 25 (OH) D capable of improving glucose homeostasis. To respond to this objective, in this study the researchers suggest a cut-off point of 25 (OH) D of 45 ng / mL to obtain these benefits.



"Based on the results of the study, we suggest that optimizing the levels of 25 (OH) D in women with postmenopausal osteoporosis and who do not present established alterations in glucose metabolism, could suppose a preventive strategy against the development of comorbidities associated with postmenopausal osteoporosis such as metabolic syndrome, type 2 diabetes or cardiovascular complications, in addition to exercising its known beneficial effect on bone health, "say Dras. Ávila-Rubio and García-Fontana, researchers of the CIBERFES group at the San Cecilio University Hospital of Granada. (Source: CIBER / DICYT)



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