A CSIC patent gives rise to a pioneering drug in the treatment of Crohn's disease

A CSIC patent gives rise to a pioneering drug in the treatment of Crohn's disease https://i2.wp.com/www.eresviral.com/wp-content/uploads/2018/11/Una-patente-del-CSIC-da-lugar-a-un-medicamento-pionero-en-el-tratamiento-de-la-Enfermedad-de-Crohn.jpg?fit=187%2C146&ssl=1

A CSIC patent gives rise to a pioneering drug in the treatment of Crohn's disease





A CSIC patent gives rise to a pioneering drug in the treatment of Crohn's disease


A patent granted to the team of Mario Delgado, researcher of the Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), center of the Superior Council of Scientific Research (CSIC) in Granada (Spain), has been the scientific basis for the creation of Alofisel, a pioneering drug that allows to treat one of the most serious complications associated with Crohn's patients, the anal fistulas, which up to now, in many patients, could only be treated with surgery.



This medicine, developed by Tigenix, a company recently acquired by the Japanese pharmaceutical Takeda, was approved for commercialization by the European Medicines Agency last March; and very recently he has obtained the Galen Prize in the category of Advanced Therapy. This recognition granted in Italy is considered the Nobel of the pharmaceutical industry. The main finding of Alofisel, and what makes it a pioneering and unique treatment in Europe, is its allogeneic nature, that is, it has as an active principle the use of adipose tissue stem cells from donors unrelated to future patients.



Delgado explains that "until now, cell therapy in general was designed to use cells from the same patient, which is known as a syngeneic treatment. With this new treatment approach, the stem cell becomes a medicine like any other. That is, it can be produced by a pharmaceutical company in large quantities and distributed anywhere in the world. Also in this case, being adipose tissue or fat, you can get many donors in the Western world through liposuction. That has broken the barriers of cell therapy. Some experts in the field, when this treatment was approved in Europe, qualified it as a discovery of the decade for these Crohn's patients. "







Bowels. (Photo: CSIC)



By definition, a patent is the protection of a novel or even unique result of an investigation, that is, the legal mechanism of the researcher or team of researchers to claim their priority right in the industrial use of an invention or the possibility of licensing it or "selling it". " To thirds. In this case, the invention or the research result of Delgado that was licensed as a patent by the CSIC to Tigenix / Takeda and that allowed the subsequent development of Alofisel, was the discovery that certain populations of stem cells present in adipose tissue could act as regulatory agents of the immune system, and that these immunoregulatory effects could be used to prevent, treat or ameliorate autoimmune diseases, inflammatory disorders and immunologically mediated diseases, including rejection of transplanted tissues and organs.



"We described that these stem cells not only had a regenerative capacity, which was what they were being used for at that moment, but they could also regulate inflammatory and autoimmune responses. We did all the preclinical development, which represented the first novelty of the investigation. The second novelty, and what has definitely changed the use of these cells, was the possibility of using them in an allogeneic manner, between donors and unrelated patients. The combination of both concepts is what was initially patented, "said Delgado. (Source: CSIC / DICYT)

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