They test a non-invasive technology to detect failures derived from the implantation of stents

They test a non-invasive technology to detect failures derived from the implantation of stents https://i0.wp.com/www.eresviral.com/wp-content/uploads/2018/10/Ensayan-una-tecnología-no-invasiva-para-detectar-fallos-derivados-de-la-implantación-de-estents.png?fit=260%2C40&ssl=1

They test a non-invasive technology to detect failures derived from the implantation of stents





They test a non-invasive technology to detect failures derived from the implantation of stents


Researchers from the Germans Trias i Pujol Research Institute (IGTP) and the CIBERCV, led by Antoni Bayés Genís, together with the Magnetism group from the Condensed Matter Physics Department of the University of Barcelona, ​​led by Professor Javier Tejada and Ferran Macià, and the CommSensLab group of the Universitat Politècnica de Catalunya (UPC) (Catalonia, Spain), directed by Professor Joan O'Callaghan, have developed a new near-field probe to non-invasively and non-ionizingly detect the presence of the metallic stents, as well as their possible structural distortions by means of microwave spectrometry (MWS). The results have been published in the scientific journal Scientific Reports.



Coronary artery disease (CAD) is the leading cause of death in developed countries. It is usually caused by atherosclerosis, characterized by accumulations of cholesterol and other fatty substances in the wall of the arteries that can form blood clots that obstruct the coronary arteries (coronary thrombosis) and are responsible for pathologies such as angina or myocardial infarction. The treatment of CAD includes changes in lifestyle to modify coronary risk factors and different drugs, but when coronary obstructions are important, it is necessary to perform a revascularization treatment through percutaneous coronary intervention (PCI) or coronary surgery.



ICP is a minimally invasive procedure whereby a balloon dilatation is performed instead of the obstruction and a small cylindrical metal prosthesis called a stent is implanted. In some cases, over time the coronary stent may fail due to a process of restenosis, that is, the proliferation of the cells of the vascular wall that ends up obstructing the stent, or by a process of thrombosis, when an obstruction occurs. sudden stent by the formation of a thrombus inside. Different phenomena have been related to an increased risk of these failures: there may be a fracture process of the metallic structure of the stent; in other cases there may be a lack of contact between the arterial wall and the stent (incomplete apposition); or sometimes there is an incomplete expansion of the stent that decreases the caliber inside.







(Photo: UPC-UB-IGTP-CIBERCV)



Currently, there is no available technology that allows to detect in a non-invasive way phenomena such as fracture, incomplete apposition or incomplete expansion of the stent or even the presence of restenosis. "Invasive techniques such as coronary angiography, intravascular ultrasound or optical coherence tomography are expensive and their use can not be generalized in all patients with coronary stents," explains Carolina Gálvez-Montón, first author of the article. In addition, these are complex techniques that require very specific machinery that is not found outside of large hospitals.



"The near-field probe consists of a device the size of a finger that emits an electromagnetic wave similar to the waves of mobile telephony and which in turn detects the changes caused to said wave due to the implanted stent" explains Ferran Macià de the UB.



To test this new probe, "subcutaneous implantation of stents has been performed in a murine model where the presence of the devices has been detected as well as their changes derived from restenosis and fracture by varying the resonance frequencies characteristic in the spectra. of absorbance of microwaves, that reflect the occurrence of changes in the length of the stent or the diameter ", explains Gálvez-Montón. As a result, since the stents were colonized with fibrotic tissue as a natural response to their subcutaneous implantation, the new probe detected significant differences in its content between its baseline implantation and at 30 days of follow-up (restenosis). Finally, it was possible to differentiate by means of microwave spectrometry the stents that were fractured from those that remained intact.



In conclusion, according to Antoni Bayés Genís, "more studies are needed to confirm these results and we believe that it is necessary to transfer these experiments to a pre-clinical level in an animal model similar to the human one, and in case of corroboration, validate this new technology in a small cohort of patients. "



"We are addressing the technological aspects that allow performing pre-clinical experiments and their eventual transfer to a clinical application", explains Joan O'Callaghan, researcher at the UPC, "this includes, among others, the development of devices capable of detecting deeper stents and detection techniques that tolerate the movement of stents implanted in coronary arteries ". (Source: UPC)

        .

  !function(f,b,e,v,n,t,s)

  {if(f.fbq)return;n=f.fbq=function(){n.callMethod?

  n.callMethod.apply(n,arguments):n.queue.push(arguments)};

  if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';

  n.queue=[];t=b.createElement(e);t.async=!0;

  t.src=v;s=b.getElementsByTagName(e)[0];

  s.parentNode.insertBefore(t,s)}(window, document,'script',

  'https://connect.facebook.net/en_US/fbevents.js');

  fbq('init', '369524843414444');

  fbq('track', 'PageView');

    .


SOURCE LINK ERESVIRAL.COM 
https://www.beviral.online