They follow a virus that causes respiratory infections in pediatric patients
They follow a virus that causes respiratory infections in pediatric patients
They follow a virus that causes respiratory infections in pediatric patients
Acute respiratory infections (ARI), many of them seasonal, are frequent, mainly in neonatal and pediatric patients. In the last ten years, new viruses that cause ARF have been detected, such as human Metapneumovirus (Mpvh) and Bocavirus (HBov).
In this context, the Laboratory of Molecular Applications of the Chair of Microbiology and Immunology of the Faculty of Medicine of the UNNE (Argentina), under the direction of Dr. Gerardo Deluca and the co-direction of Dr. Ailín Sotelo, develops, from the year 2014, an intense task to know more about the Bocavirus (HBov) and especially to find a detection methodology.
The human Bocavirus (HBov), discovered in 2005, can cause different affections of the respiratory tree, particularly in the population younger than 2 years. However, epidemiological information on this agent in northern Argentina is still scarce.
To know the frequency and seasonality of HBov infections, in the province of Chaco during the 2014-2016 period, approximately 1210 children with presumptive diagnosis of ARF were evaluated. The detection of respiratory agents is performed from nasopharyngeal aspirates using multiplex format molecular biology techniques, which allows detecting most of the IRA producing microorganisms at once and in a single sample in a fast, simple and effective manner.
(Photo: Argentina Investigates)
51.8% of the analyzed samples were positive for one or more of the agents evaluated. The months of greatest frequency of the HBov were the months of June to September. In those months, 82.9 percent of the total positive cases were detected. 83.8% were observed in patients younger than 18 months, this being the age group with the highest infectivity of the three epidemiological years analyzed.
In 40.5 percent, HBov was coinfected with other respiratory pathogens. Based on the figures extracted from the work -developed by the team of doctors Deluca and Lifschitz- it is clearly shown that HBov is an agent that occurs at a not insignificant frequency in Acute Respiratory Infections, in patients younger than 2 years .
Since the discovery of HBov, epidemiological work has been increasing and was detected throughout the world in nasopharyngeal samples, serum and feces. These studies showed that HBoV could be responsible for a not insignificant percentage of bronchiolitis and recurrent wheezing in young children.
The work shows a frequency of infection by HBoV of 9.1% (for the period 2014-2016) in children under 5 years, a similar percentage to that found by other jobs in the center of the country. A clear seasonality is observed between the months of June-September, this being a very important information for the pediatric clinical system when evaluating ARI.
For Deluca "there are still points to be clarified regarding infection by this agent, and describing its circulation in different regions of our country is a first step towards the goal of achieving greater clarity about its pathogenic role."
One of the main concerns that generated the development of this project is the current limitation to the diagnosis of viral agents associated with acute infections of the lower airways and the ignorance that exists in the Northeast on the epidemiology of "New Viruses", given the scarce amount of research work done so far to verify the impact of the same.
This was, until very recently, a reflection of the lack of importance given to the etiological diagnosis of viral infections, particularly due to the lack of specific chemotherapy treatment. Currently, this trend is reversed for multiple reasons.
In this sense, the appearance of new antiviral drugs such as, for example, Oseltamivir for FluA and monoclonal antibodies for RSV play an important role. In addition, another factor that drives the growing interest in specific viral diagnosis are the multiple disadvantages that are registered by the inappropriate and indiscriminate use of antibiotics, when they are not necessary. (Source: Argentina Investiga)
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SOURCE LINK ERESVIRAL.COM https://www.beviral.online
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