The combination of two biomarkers improves the detection of sepsis in surgical patients
The combination of two biomarkers improves the detection of sepsis in surgical patients
The combination of two biomarkers improves the detection of sepsis in surgical patients
Scientists from the Biomedical Research Group in Sepsis (BioSepsis) of the University Clinical Hospital of Valladolid / IECSCYL, the Rio Hortega University Hospital in Valladolid and the University Hospital of Salamanca (Spain) have discovered and validated that the combination of two biomarkers, procalcitonin ( PCT) and the levels of HLA-DRA gene expression, which can be obtained through a blood test, improves the detection of sepsis in surgical patients, which was a great challenge. The work has been published in the journal Nature 'Scientific Reports'.
The early recognition of sepsis in these surgical patients is currently an important challenge for specialists. Sepsis is a very serious disease that appears as an inadequate response of the organism to infection in predisposed subjects. According to data from the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC), there are about 50,000 cases per year in Spain and about 17,000 deaths, being one of the main causes of mortality in developed countries.
"And it's about conservative data," Jesús Bermejo, head of the BioSepsis Group, told DiCYT. "Sepsis increasingly affects more people, since life expectancy has increased a lot and the disease often occurs in elderly patients and people with chronic diseases, such as diabetes, hypertension or chronic obstructive pulmonary disease," he says.
The combined quantification of procalcitonin and HLA-DR improves the detection of sepsis in surgical patients. (Photo: Almansa et al. 2018 / Scientific Reports)
Sepsis causes organ failure and is triggered quickly. Therefore, specialists have to treat it with haste, since the evolution of the patient depends a lot on the time that passes until it is detected and treatment is started: eliminating the infection focus, administering antibiotics and maintaining vital signs. " For every hour of delay in the start of treatment there is a 10 percent more chance of mortality, "warns the researcher.
However, the detection of the disease is complicated in patients who have undergone surgery, since the inflammation that causes sepsis can be confused with the inflammation characteristic of the surgical intervention. To help specialists detect it as soon as possible, researchers look for biomarkers, that is, molecules whose expression is either very high or very small in patients with sepsis.
"We have combined two biomarkers, a marker of inflammation that is commonly used in hospitals along with clinical signs and other tests to identify sepsis, procalcitonin (PCT), and one that measures how the patient is immunologically, the expression of HLA- DRA. With this combination we have managed to improve the sensitivity of the method by 7 percent, "says Bermejo.
The study developed has two major parts. In the first, carried out on a cohort of 154 surgical patients (101 with sepsis and 53 without infection) from the two hospitals of Valladolid, the potential of the combination of both biomarkers was discovered. In the second, in which patients from the Hospital Clínico de Salamanca were added, the validity of this strategy was confirmed.
"This is an example that from Castilla y León, and from the Public Health, you can perform cutting-edge research on problems of the first order, such as sepsis. To continue advancing in this line we have created the BioSepsis group that seeks to respond to the needs of physicians who treat these patients and need to detect and better manage the disease, "he concludes. (Source: Cristina G. Pedraz / DICYT)
.
!function(f,b,e,v,n,t,s)
{if(f.fbq)return;n=f.fbq=function(){n.callMethod?
n.callMethod.apply(n,arguments):n.queue.push(arguments)};
if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';
n.queue=[];t=b.createElement(e);t.async=!0;
t.src=v;s=b.getElementsByTagName(e)[0];
s.parentNode.insertBefore(t,s)}(window, document,'script',
'https://connect.facebook.net/en_US/fbevents.js');
fbq('init', '369524843414444');
fbq('track', 'PageView');
.
SOURCE LINK ERESVIRAL.COM https://www.beviral.online
Comentarios
Publicar un comentario