Discovered a mechanism of genetic transfer of superbugs to create resistance to antibiotics
Discovered a mechanism of genetic transfer of superbugs to create resistance to antibiotics
Discovered a mechanism of genetic transfer of superbugs to create resistance to antibiotics
Researchers from the University of Glasgow and the National University of Singapore published in the journal Science the discovery of a mechanism of genetic transfer of the hitherto unknown bacteria, lateral transduction, by which they are transformed into superbugs resistant to antibiotics. extremely fast The Spanish, José Rafael Penadés, collaborating researcher of the Department of Biomedical Sciences of the CEU UCH (Spain) who currently works at the University of Glasgow, has led the team that created this finding.
According to José R. Penadés, "this new form of genetic evolution of bacteria, which we have described for the first time, could be up to ten thousand times faster and more efficient than the mechanisms known up to now. Therefore, this finding will allow the scientific community to better understand how bacteria rapidly develop new resistance to known antibiotics, becoming superbacteria for which treatments are not effective. "
The new gene transfer process described in his work published today by Science, called lateral transduction, adds to the two mechanisms known until now of transduction of genetic material between bacteria by the action of viruses: general transduction and specialized transduction, both discovered by the Nobel Prize in Medicine Joshua Lederberg. The research team, led by the Spanish José R. Penadés, believes that, due to its efficiency and speed with respect to the processes already known, this could be the most revolutionary finding in the field of bacterial transduction.
José R. Penadés. (Photo: CEU-UCH)
In this sense, Professor Penadés emphasizes: "The discovery is very significant, not only because we have been able to find an unknown mechanism that allows the rapid evolution of bacteria, but also because of its relevance in the current context of growth of resistance to antibiotics Lateral transduction represents a true turning point in our understanding of the process of bacterial evolution. "
Bacterial transduction is a process that bacteria suffer when they are infected by viruses. In this process, the DNA of the infected bacterium is transferred to another bacterium, generating an evolutionary genetic mutation that increases the antibiotic resistance capacity of the recipient bacterium. The lateral transduction now discovered by Dr. Penadés's team is unique in its efficiency: "In this process, so many genes are transferred from one bacteria to another, that all the sections of the bacterial chromosome could be considered to be mobilized at the same time, which would explain the rapidity with which bacteria are transformed into superbugs, that is, into bacteria resistant to several types of antibiotics. "
According to the researcher John Chen, from the National University of Singapore, who has worked with the Spanish José R. Penadés in this finding, "viruses, agents of bacterial transduction, are the most abundant biological entities on the planet. And the importance of transduction as a key mechanism of microbial evolution has never been as clear as after this finding of lateral transduction. " (Source: CEU-UCH / DICYT)
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