Chinese researchers create healthy mice with 2 biological mothers and without a father
Chinese researchers create healthy mice with 2 biological mothers and without a father
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October 14, 2018
Chinese researchers create healthy mice with 2 biological mothers and without a father
On the list titled "What could go wrong?", Removing men from the act of reproduction is, rightly, near the top of lists compiled by men, and possibly should also be near the top of the list. the lists of women. However, that has not stopped those skilled in the CRISPR gene editing technique from successfully editing the men of the equation ... at least for the mice. Are humans the following? What was the name of that book by John Steinbeck again?
"We were interested in the question of why mammals can only undergo sexual reproduction."
In other words, why are mammals incapable of natural parthenogenesis or asexual reproduction? That question challenged Qi Zhou and other researchers from the Chinese Academy of Sciences to experiment with mice in an attempt to create offspring from pairs of females or pairs of males using CRISPR to edit haploid embryonic stem cells: stem cells that only half of a set of chromosomes. These cells still contain the genomic printing media that automatically stop the development of cells that have no male and female genetic material, resulting in abnormal or non-viable offspring: one of those bad / good things that nature provides.
It does not take a rocket or a genetic scientist to discover what happened next.
"The researchers created the mice with two mothers by removing three imprint regions of the haploid ESC genome that contained a mother's DNA and injected them into the eggs of another female."
At Press release announcing the publication of the study in Cell stem cell, co-author Qi Zhou describes what went wrong and what apparently went well. A total of 210 embryos were created and 29 managed to survive and develop in "normal" adult mice that reproduced by themselves using the normal method.
Things did not work so well with the haploid embryonic stem cells of men. They needed a more extensive edition to eliminate their genetic printing mechanisms and had to be placed in an egg that was also edited to eliminate its nucleus that contains female genes. Despite this, 12 embryos survived, but only for two days. (Long enough to hear the booing of female mice?) Not surprisingly, male scientists plan to keep trying with two males.
I have found someone else.
Why?
"This research shows us what is possible, we saw that the defects in bimaterous mice can be eliminated and that the barriers of biparnal reproduction in mammals can also be crossed through the modification of the impression." We also reveal some of the most important printed regions that hinder the reproduction. development of mice with parents of the same sex, which are also interesting to study the genomic imprinting and the cloning of animals. "
The sexual act is easy. Maybe that's why nature made everything so complicated and complicated. Researchers have already succeeded in developing human haploid embryonic stem cells.
What is the name of that list again?
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