A project was awarded to combine two innovative treatments against cancer
A project was awarded to combine two innovative treatments against cancer
A project was awarded to combine two innovative treatments against cancer
Irati Rodrigo Arrizabalaga, PhD student of the MIMASPEC research group of the Faculty of Science and Technology of the UPV / EHU (Spain) has won an international award at the summer school organized by the "IEEE Magnetic Society", the largest magnet society in the world. world. The project aims to combine two novel treatments against colorectal cancer. On the one hand, magnetic hyperthermia and, on the other hand, magnetomechanical destruction.
Both therapies are being developed independently but have never been applied together. "Magnetic hyperthermia is an innovative therapy against cancer: the magnetic nanoparticles strategically placed in the tumor tissues absorb energy from an external radiofrequency magnetic field and act as a source of heat, destroying cancer cells due to the increase in temperature", explains the researcher of the UPV / EHU Irati Rodrigo.
The magnetomechanical destruction is also an emerging treatment against cancer that involves implanting magnetic particles in the form of discs in the tumor and applying a low frequency alternating magnetic field. "This generates an oscillating movement of the discs, which transmit a mechanical force to the cell, being able to break its membrane and consequently generate its death", explains Rodrigo.
Therefore, in the first therapy the cancer cells are destroyed by increasing the temperature of the area and in the second by mechanical movement of the particles. "Both, unlike conventional oncological therapies, have the potential to attack cancer-causing tissues without damaging healthy ones and without the need for surgery," he points out.
(Photo: UPV / EHU)
"Currently, these two treatments are in development and are not 100% effective. Therefore, we hope that when they are combined, more cancer cells will be destroyed than when they are applied individually, "says Rodrigo.
The prize awarded by "IEEE Magnetic Society 'consists of a financing of 5,000 pains (€ 4350) for the practical realization of this project to treat colorectal cancer. The project was proposed by Irati Rodrigo along with three other young researchers: Emma Welbourne and Michael Stanton of the University of Cambridge, England, and Daniela Valdés of the Balseiro Institute in Bariloche, Argentina.
In September the group moved to Cambridge to study the interaction between colon cancer cells and the particles used in both treatments (in each therapy different particles are used, nanoparticles in hyperthermia and microdisks in magnetomechanics).
"Understanding the interaction between different types of particles is important to see how they are going to act once the two treatments are applied together. In addition, it is vital to analyze where the particles are located once located in the tumor zone to understand the way in which they can damage it or not. For this we have used different microscopy techniques and we have observed their location and configuration ".
Irati Rodrigo and the other three young researchers are currently in the Faculty of Science and Technology of the UPV / EHU to apply the treatment in the teams previously developed by the research group of the UPV / EHU MIMASPEC, in which they develop their Rodrigo thesis.
"Here, in Leioa, we will apply magnetic hyperthermia with the equipment developed by my research group. We will use cell cultures to which the particles used in both treatments and synthesized by my project partners have been added. On the other hand, we will apply magnetomechanical destruction with equipment designed and brought from the University of Cambridge. Finally, both treatments will be applied together to the same cell culture to evaluate a possible improvement.
The project is under development and the results will be presented in January 2019 at the conference "2019 Joint MMM-Intermag", the most important magnetism conference in the world, to be held in Washington (USA). "We hope that part of the cells that are not destroyed by one of the treatments, are the other."
Irati Rodrigo Arrizabalaga (Bilbao, 1989) is a PhD candidate at the MIMASPEC Research Group of the Faculty of Science and Technology of the UPV / EHU and a researcher at BCMaterials - Basque Center for Materials, Applications and Nanostructures. At the moment he is doing his thesis entitled 'Development of new experimental techniques for magnetic hyperthermia'. The award-winning project arises in the international course "IEEE Magnetic Summer School" which Irati attended last July in Quito and where attendees presented different projects that they would like to lead and carry out. (Source: UPV / EHU)
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