Researchers at the UCV discover the influence of exosomes on macular degeneration associated with age

Researchers at the UCV discover the influence of exosomes on macular degeneration associated with age https://i0.wp.com/www.eresviral.com/wp-content/uploads/2018/11/Investigadores-de-la-UCV-descubren-la-influencia-de-los-exosomas-en-la-degeneración-macular-asociada-a-la-edad.jpg?fit=219%2C146&ssl=1

Researchers at the UCV discover the influence of exosomes on macular degeneration associated with age





Researchers at the UCV discover the influence of exosomes on macular degeneration associated with age





Researchers from the Neurobiology and Neurophysiology team of the Faculty of Medicine of the Catholic University of Valencia (UCV) (Spain), led by Jorge Barcia, have discovered that exosomes - microscopic extracellular particles that are released from all cells - come from the epithelium Retinal pigments promote neovascularization processes, a finding that could be intimately related to the processes of the same type in age-related macular degeneration (AMD).



In this sense, UCV researchers suggest that in the future it will be possible to diagnose diseases such as AMD "by analyzing the exosomal content of a sample of blood or other biological fluids".



The team of the Faculty of Medicine has published their findings in an article in the scientific journal Journal of Cellular and Molecular Medicine (Revista de Medicina Celular y Molecular). In the same, UCV researchers explain how they have observed that "if the retinal pigment epithelium cells are subjected to stress release exosomes that facilitate the generation of new blood vessels, analogous to what happens in the DMAE" . This exaggerated growth of the vessels is due to the fact that these exosomes contain "a large proportion of the VEGFR-2 protein".







(Photo: UCV)



AMD is a disease that causes loss of vision and affects older people. Frequently, this pathology manifests itself with an "overgrowth" of new blood vessels in this area, "vessels that are fragile and very permeable, producing alterations that result in spots in the central vision". This process affects especially the macula, the area of ​​the retina responsible for acute vision, "so it is difficult to see the details as occurs for example in reading."



"Until a few years ago it was thought that the role of these vesicles was the release of 'cellular garbage' to the outside. However, nowadays it is known that exosomes contain genetic material, proteins and lipids, so they can transport this intact material from one cell to another ", explain the UCV researchers.



Thus, the discovery of exosomes has allowed "enormous" advances in fields as different as oncology, (exosomes play an important role in metastasis), neurodegenerative diseases (such as Alzheimer's or Parkinson's) and even diseases that lead to blindness . It has also been seen that the composition of exosomes changes according to their cellular origin and according to the state of health of the cell. (Source: UCV)



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