They make esophageal tissue grow from stem cells in a laboratory
They make esophageal tissue grow from stem cells in a laboratory
Scientists who work with the objective of reproducing the entire human gastrointestinal system in a laboratory have now managed, through the use of pluripotent stem cells, to grow organoids ("buds") of human esophagus.
This is the most recent advance of the team of Jim Wells, expert of a center specialized in medicine of stem cells and organoids attached to the Medical Center of the Children's Hospital of Cincinnati in the United States.
The institution is working on the development of new ways of studying birth defects and congenital diseases that cause gastrointestinal problems to millions of people. This line of research is leading to new personalized diagnostic methods and it is expected that, in the long term, it will lead to therapies for tissue regeneration aimed at treating or curing gastrointestinal conditions.
The most recent achievement of Wells and his colleagues is, as far as they know, the first time that human tissue of the esophagus is grown exclusively from pluripotent stem cells. These stem cells can form any type of tissue in the body.
The esophagus is a muscular tube that actively moves food from the mouth to the stomach. The organ can be affected by malformations and other congenital problems derived from genetic mutations that cause its narrowing or other harmful effects.
This image, from a confocal microscope, shows an organoid of the human esophagus two months after beginning to form by induction of the scientists from pluripotent stem cells. With a size of about 700 micrometers, the organoid has been stained to allow to see better in it the essential structural proteins expressed in the mature esophagus. (Photo: Cincinnati Children's Hospital Medical Center)
Other diseases affect the esophagus and can severely reduce the quality of life of patients or even threaten their lives. These include esophageal cancer, gastroesophageal reflux disease, or a rare condition called esophageal achalasia, which affects the muscles of the lower esophagus and prevents contraction of the organ and passage of food.
All these conditions need better treatments and finding them requires a deeper knowledge of the genetic and biochemical mechanisms underlying the causes of such ailments. This need for detailed information can be met through the ability to generate and study robust and functional models, genetically coincident, of human tissue of the esophagus that can grow from a person's own cells.
.
!function(f,b,e,v,n,t,s)
{if(f.fbq)return;n=f.fbq=function(){n.callMethod?
n.callMethod.apply(n,arguments):n.queue.push(arguments)};
if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';
n.queue=[];t=b.createElement(e);t.async=!0;
t.src=v;s=b.getElementsByTagName(e)[0];
s.parentNode.insertBefore(t,s)}(window, document,'script',
'https://connect.facebook.net/en_US/fbevents.js');
fbq('init', '369524843414444');
fbq('track', 'PageView');
.
SOURCE LINK ERESVIRAL.COM https://www.beviral.online
Comentarios
Publicar un comentario