The antiparasitic ivermectin is six times more toxic than moxidectin
The antiparasitic ivermectin is six times more toxic than moxidectin
Ivermectin is six times more toxic than moxidectin for the insects responsible for the recycling of organic matter. For the first time there is scientific evidence based on physiological studies and should be taken into account when using antiparasitic agents for livestock.
This is the conclusion of the study carried out by the multidisciplinary research group led by José R. Verdú, Professor of Zoology and researcher of the Ibero-American Center for Biodiversity (CIBIO) of the University of Alicante (Spain) and in which they have participated scientists of the CIBIO and the Department of Physiology, Genetics and Microbiology of the UA; the University of Jaén, Université Paul Valéry Montpellier 3; the National Museum of Natural Sciences-CSIC; the University of Granada; and the IUCN-Center for Mediterranean Cooperation.
The results have just been published in the article First assessment of the comparative toxicity of ivermectin and moxidectin in adult dung beetles: Sub-lethal symptoms and pre-lethal consequences, included in the journal Nature Scientific Reports. By means of a comparative study on the toxicity of ivermectin and moxidectin molecules in the population of adult dung beetles, scientists have concluded that the ivermectin molecule is six times more toxic than moxidectin. With this result in hand scientists recommend to veterinarians and ranchers the use of moxidectin as an alternative to take into account in deworming livestock, replacing ivermectin and to avoid the serious consequences that Biodiversity has on the use of is.
Ivermectin is a very effective antiparasitic, used preventively in cattle, since its discovery in 1981. Since then it has experienced an exponential growth, until becoming a standard treatment against parasites, even in humans. It is considered by the World Health Organization (WHO) as an essential medicine.
Cattle. (Photo: UPV)
Currently, ivermectin is the most widely used molecule worldwide and also one of the most toxic for beneficial fauna, says José R. Verdú. The scientists compared the two molecules and found that moxidectin "would be a good alternative to use it instead of ivermectin. At the physiological level of insects, it affects a lot less. " The study has been carried out both at the physiological and behavioral level of pelotero beetles, obtaining direct results on how it affects the coleoptera. The physiological study (sub-lethal) analyzes whether it affects the organs, antennas, etc., and behavioral (pre-lethal), which takes into account if the legs are uncoordinated or if the beetle is paralyzed.
The methodology of work followed, Verdú details that has consisted in the realization of two tests: electroantenografía, which consists of a test to see how healthy are the antennae and the smell of insects. For this they had individuals who had ingested different concentrations of these molecules and, in this way, have been able to see how the antennas receive the stimulus, how was the state of the antennas.
The second test has tried to see the motility behavior, that is, walking, stretching antennas, moving legs; Researchers have detected symptoms, such as partial paralysis, ataxia or total paralysis and, depending on this, point out how many days have taken to have that paralysis. "In the case of ivermectin, ataxia occurs much earlier in time."
The researcher of the UA affirms that, although "it was known that this molecule was less toxic, however, with the beetles the study had not been applied at the physiological level". In the echo toxicity analyzes carried out, the appropriate parameters have been used, the limits of toxicity, "with this it is much more reliable". They are parameters that are used in the eco toxicity tests. Eco toxicity studies the effect of toxic chemical compounds on living beings, especially in terms of populations, communities and ecosystems, with the aim of being able to predict the effects of pollution to prevent any environmental deterioration effect that can be identified .
"Ivermectin is the one used in more than 90% of cases. Many pharmaceutical companies have commercialized it because it is much more effective but also more harmful to the coprophage fauna that eliminates livestock manure. " Moxidectin says "there is this alternative that has a similar effect in deworming. It is the veterinarians who have to take this alternative into account, "says Verdú.
In 2017, the same multidisciplinary team already confirmed how ivermectin is affecting the decline of coprophagous fauna, scientific results published in the study "Ivermectin residues disrupt dung beetle diversity, soil properties and ecosystem functioning: An interdisciplinary field study", in Science of The Total Environment. Thus, livestock treated with ivermectin causes the accumulation of five times more excrement per hectare per year than organic or ecological livestock.
Previously, in 2015, the research team published "Low doses of ivermectin cause sensory and locomotor disorders in dung beetles" in the journal Scientific Reports. On that occasion, they analyzed the effect of the drug ivermectin on the populations of Scarabaeus cicatricosus, a key coprophagous beetle in Mediterranean ecosystems. The research showed that arthropods that ingest this substance, even in low doses, lose their ability to interact with the environment because they have altered their locomotor and sensorial capacities, a fact that may explain the decline that populations of these beetle species are suffering. (Source: UA / DICYT)
.
!function(f,b,e,v,n,t,s)
{if(f.fbq)return;n=f.fbq=function(){n.callMethod?
n.callMethod.apply(n,arguments):n.queue.push(arguments)};
if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';
n.queue=[];t=b.createElement(e);t.async=!0;
t.src=v;s=b.getElementsByTagName(e)[0];
s.parentNode.insertBefore(t,s)}(window, document,'script',
'https://connect.facebook.net/en_US/fbevents.js');
fbq('init', '369524843414444');
fbq('track', 'PageView');
.
SOURCE LINK ERESVIRAL.COM https://www.beviral.online
Comentarios
Publicar un comentario