Rapid and cost-effective production of small quantities of various biopharmaceuticals
Rapid and cost-effective production of small quantities of various biopharmaceuticals
Biopharmaceuticals, a class of drugs that includes antibodies and hormones, represent a rapidly growing sector within the pharmaceutical industry. They are increasingly important for "precision medicine". This consists of using drugs adapted to the genetic or molecular profiles of particular patient groups.
Such drugs are usually manufactured in large facilities dedicated to a single product, using processes that are difficult to reconfigure. This rigidity makes manufacturers tend to focus on drugs that are necessary for many patients, while the production of those that only serve smaller groups of patients can be postponed indefinitely.
Many biopharmaceuticals are produced in devices known as "bioreactors," where bacterial, yeast, or mammalian cells produce large amounts of a single drug. However, the drugs thus prepared must be purified in order to be used, so that the entire production process can include dozens of steps, many of which require human intervention. As a result, it may take weeks to months to produce a single batch of a drug.
To help improve the availability of these minority-use drugs, the team of J. Christopher Love, Laura Crowell, Amos Lu and Kerry Routenberg Love, of the Massachusetts Institute of Technology (MIT), in Cambridge, United States, has developed a new system that can be easily reconfigured to produce different drugs, allowing a flexible change between products as needed and being able to quickly manufacture biopharmaceuticals on demand.
The new system can easily be reconfigured to manufacture small quantities of different biopharmaceuticals. (Image: Felice Frankel, Christine Daniloff, MIT)
Love and his colleagues have used this manufacturing system, which can fit into a common laboratory table, to produce three different biopharmaceuticals: a human growth hormone, a compound used to treat cancer, and another that is used to increase the potency of the immune systems of patients who are receiving chemotherapy.
Love's team has verified that for these three cases, the drugs produced with the new process have the same biochemical and biophysical traits as the versions manufactured in a conventional manner and on a commercial scale.
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