A drug for inflammatory bowel disease attacks a safe haven for HIV

A drug for inflammatory bowel disease attacks a safe haven for HIV https://i2.wp.com/www.eresviral.com/wp-content/uploads/2018/10/Un-fármaco-para-la-enfermedad-inflamatoria-intestinal-ataca-a-un-refugio-seguro-para-el-VIH.png?fit=260%2C40&ssl=1

A drug for inflammatory bowel disease attacks a safe haven for HIV









	
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A drug for inflammatory bowel disease attacks a safe haven for HIV





A first study in patients with inflammatory bowel disease (IBD) and HIV found that the administration of a drug for IBD interrupts the concentration of infected HIV T cells in the intestine that form a constant reservoir of infection.



The compound, called vedolizumab (VDZ), could one day be of help in research efforts to develop a cure for HIV. Although modern antiviral drugs can keep HIV at bay, there is still no treatment to eliminate the virus from the body. A key obstacle is the ability of the virus to infect T cells that reside in the tissues of the mucosa of the gastrointestinal (GI) tract.



Reduction or elimination of this viral deposit is a primary goal for HIV researchers, but additional research is needed to develop a safe and effective therapy. On this occasion, Mathieu Uzzan et al. they focused on T cells harboring a4ß7, a protein that participates in the migration of immune cells to certain parts of the GI tract.



The authors administered VDZ, which is currently a first-line treatment for IBD targeting 4ß7, to a group of six patients with IBD who were also HIV positive and monitored them for 30 weeks by blood tests and colonoscopies performed before and after the treatment.



VDZ prevented the formation of accumulations of T cells in the small intestine of the subjects and proved to be safe throughout the study. The authors state that these results support the idea that anti-a4ß7 therapy could be an important tool in the current search for HIV eradication. (Source: AAAS)



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